Protein Details: Gamma-aminobutyric acid receptor subunit beta

Protein ID

ICDB_Pro_0189

Protein Name

Gamma-aminobutyric acid receptor subunit beta

Gene Name

gab-1; ZC482.1

Organism

Caenorhabditis elegans

Length

550 amino acids

AlphaFoldDB

AF-O18276-F1-model_v4.pdb

Function

GABA; an inhibitory neurotransmitter; mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel.

Sequence

MRRSKTRRIFHVSITLLLVSTIFCQNGTKPHNNSTSDQMSSSWSNRSQTMYSNASSLLSDLLLDYDIRLRPGFGGDALLLTMDIIIASFDSISEVDMDYTLTMYLHQYWTDERLRWSNEIPIDEMTLSGEFSQNIWVPDTFLANDKHSYLHEVTERNKMLRINVDGKVAYGMRLTSTLSCSMNLRNFPLDSQNCTVEIESYGYTTSEVLMKWNYPLAVHGVEQADVPQFTITGFHTEDSIVSTATGSYQRLSLVFQLRRSVGYFIFQTYLPCVLIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRQSLPRISYVKSIDIYLVMCFVFVFAALLEYAAVNYSYWGRERGKGGGGNEWPVNGANKEDRESAVNVQKWVPSGLMDGVPQPQDRRVEALEEAMSTSNTAAQNNNFESTSKPKKRSSSPIPPLCRAGNTISEESESPDYPRYSTTSLKGARPHASLNHKTHHLKGRSSARAKRRMTLARMNVSMKQSISGIGRRARKVIPTIRVRDVNLIDKYSRVVFPVCFIVFNLFYWSYYMMVPS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1046/j.1471-4159.2002.01199.x; 10.1126/science.282.5396.2012

RefSeq

NP_499661.2